I’m seeing a couple possibilities here for a overnight paddle and camp trip. The first one is just heading straight down the main body of the Santee river starting at Jamestown, SC.
Day 1: Echaw Creek-McConnell’s Landing
Day 2: McConnell’s Landing – Wambaw Creek (via Chicken Creek)
According to the available info both segments are about 4-5 hours paddling time. That will leave us time to stop and fish along the way and not be in a rush to get to the landing. Also, the entire southern bank is national forest land. Several more landing spots not on the map are available for camping/stopping.
Jamestown-Santee river:
https://berkeleyblueways.com/2017/10/13/jamestown-santee-river/
https://www.sctrails.net/trails/trail/jamestown-santee-river
The other possibility is starting in a tributary to the river, but ending up in the same place.
Wambaw Creek:
Click to access stelprd3796939.pdf
https://www.sctrails.net/trails/trail/wambaw-creek
WARNING: THIS VIDEO CONTAINS QUESTIONABLE MUSIC CHOICES
Echaw Creek:
https://berkeleyblueways.com/2016/07/19/echaw-creek/
https://www.sctrails.net/trails/trail/echaw-creek
Click to access stelprdb5346213.pdf
Chicken Creek:
yak-fish-camp 